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Found 855 from Galderma Research & Development
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50606735(CHEMBL5219718 | US11731973, Example 3)
Affinity DataKi:  0.300nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50606737(CHEMBL5218727 | US11731973, Example 5)
Affinity DataKi:  0.400nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50606738(CHEMBL5218590 | US11731973, Example 6)
Affinity DataKi:  0.5nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50606740(CHEMBL5220536 | US11731973, Example 30)
Affinity DataKi:  0.580nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50606742(CHEMBL5220948 | US11731973, Example 9)
Affinity DataKi:  0.600nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50606739(CHEMBL5220152 | US11731973, Example 7)
Affinity DataKi:  0.600nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613740(3-(2-aminobenzoxazol-5-yl)-1-(2,2- dimethylbutyl)-...)
Affinity DataKi:  0.600nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50606741(CHEMBL5219710 | US11731973, Example 1)
Affinity DataKi:  0.800nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613743(1-(2,2-dimethylpropyl)-3-(2- ethylaminobenzoxazol-...)
Affinity DataKi:  0.800nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50606736(CHEMBL5218916 | US11731973, Example 10)
Affinity DataKi:  0.800nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613734(3-(2-amino-6-fluorobenzoxazol-5-yl)- 1-((S)-1,3-di...)
Affinity DataKi:  1nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613744(3-(2-aminobenzoxazol-5-yl)-1-(2,2- dimethylbut-3-e...)
Affinity DataKi:  1.20nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613745((+)-3-(2-aminobenzoxazol-5-yl)-1- ((S)-2-methyl-2-...)
Affinity DataKi:  1.20nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613746(3-(2-aminobenzoxazol-5-yl)-1-(2,2- dimethylbut-3-y...)
Affinity DataKi:  1.20nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613736(3-(2-amino-6-fluorobenzoxazol-5-yl)- 1-(1-methylcy...)
Affinity DataKi:  1.40nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613748(3-[4,6-diamino-3-(2- aminobenzoxazol-5-yl)pyrazolo...)
Affinity DataKi:  1.5nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613749(3-(2-aminobenzoxazol-5-yl)-1-(2- methyl-2-methylsu...)
Affinity DataKi:  1.70nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613750(3-(2-amino-4-chlorobenzoxazol-5-yl)- 1-(2,2-dimeth...)
Affinity DataKi:  1.80nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582476(5-(2-aminobenzoxazol-5-yl)-7-isobutyl-7-methyl-6, ...)
Affinity DataKi:  2nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613751(3-(2-amino-6-methoxybenzoxazol-5- yl)-1-(2,2-dimet...)
Affinity DataKi:  2.10nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613752(2-[4,6-diamino-1-(2,2- dimethylpropyl)-1H-pyrazolo...)
Affinity DataKi:  2.30nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582489(5-(2-aminobenzoxazol-5-yl)-7-isobutyl-7-methyl-6,7...)
Affinity DataKi:  2.40nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613753(3-(2-amino-6-methoxybenzoxazol-5- yl)-1-(2,2-dimet...)
Affinity DataKi:  2.90nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582479(5-(2-aminobenzoxazol-5-yl)-7-methyl-7-methylsulfan...)
Affinity DataKi:  3.60nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50529395(CHEMBL4529672 | US11731973, Example 21)
Affinity DataKi:  3.80nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613755(3-(2-aminobenzoxazol-5-yl)-1-(2- ethyl-2-methanesu...)
Affinity DataKi:  3.90nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613756(3-(2-aminobenzoxazol-5-yl)-4-chloro- 1-isobutyl-1H...)
Affinity DataKi:  5.80nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50529393(CHEMBL4564479 | US11731973, Example 24)
Affinity DataKi:  6.10nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582490(5-(2-aminobenzoxazol-5-yl)-7-methyl-7-methylsulfan...)
Affinity DataKi:  8nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613758(3-(2-amino-6-chlorobenzoxazol-5-yl)- 1-((S)-1,2-di...)
Affinity DataKi:  8.10nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582482(5-(2-aminobenzoxazol-5-yl)-7-methyl-7-propyl-6, 7-...)
Affinity DataKi:  8.70nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM50529398(CHEMBL4549761 | US11731973, Example 31)
Affinity DataKi:  10nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582478(5-(2-aminobenzoxazol-5-yl)-7-isobutyl-6, 7-dihydro...)
Affinity DataKi:  11.7nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613759(3-(2-aminobenzoxazol-5-yl)-1- isopropyl-N*6*-methy...)
Affinity DataKi:  13.4nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613760(5-(6-amino-4-methyl-1-neopentyl- 1H-pyrazolo[3,4-d...)
Affinity DataKi:  14.3nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613761(3-(2-cyclopropylaminobenzoxazol-5- yl)-1-isopropyl...)
Affinity DataKi:  21nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582480(5-(2-aminobenzoxazol-5-yl)-7,7-diethyl-6, 7-dihydr...)
Affinity DataKi:  34.6nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582481(5-(2-aminobenzoxazol-5-yl)-7,7-dimethyl-6, 7-dihyd...)
Affinity DataKi:  37.8nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582487(US11518767, Example 12 | tert-butyl 4'-amino-5'-(2...)
Affinity DataKi:  50.5nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582488(5-(2-aminobenzoxazol-5-yl)-7-methyl-7-methylsulfan...)
Affinity DataKi:  51.6nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582484(4-amino-5-(2-aminobenzoxazol-5-yl)-7,7-dimethyl-5,...)
Affinity DataKi:  55.8nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM613762(3-(2-amino-7-methylbenzoxazol-5- yl)-1-(2,2-dimeth...)
Affinity DataKi:  102nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582486(US11518767, Example 11 | tert-butyl 4'-amino-5'-(2...)
Affinity DataKi:  110nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582477(5-(2-aminobenzoxazol-5-yl)-7-isobutyl-7-methyl-6, ...)
Affinity DataKi:  130nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582483(5-(2-aminobenzoxazol-5-yl)-7,7-diethyl-6-methyl-6,...)
Affinity DataKi:  213nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM582485(1-acetyl-4'-amino-5'-(2-aminobenzo[d]oxazol- 5-yl)...)
Affinity DataKi:  229nMAssay Description:The model for screening the inhibitory activity of the molecules on mTOR was developed with the LANTHASCREEN™ technology (Lifetechnologies). The reac...More data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM291172(2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfuran-2-yl)...)
Affinity DataIC50:  1.30nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
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TargetC-C chemokine receptor type 6(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM172369(US9090596, 50)
Affinity DataIC50:  1.40nMAssay Description:The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were add...More data for this Ligand-Target Pair
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TargetC-C chemokine receptor type 6(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM291181(6-chloro-2-hydroxy-N,N-dimethyl-3-(2-{[(5-methylfu...)
Affinity DataIC50:  1.60nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
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TargetC-C chemokine receptor type 6(Homo sapiens (Human))
Galderma Research & Development

US Patent
LigandPNGBDBM172372(US9090596, 53)
Affinity DataIC50:  1.90nMAssay Description:The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were add...More data for this Ligand-Target Pair
In DepthDetails US Patent
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